Search Result
Gene Summary for MIR448 Gene
| Official Symbol |
MIR448 |
Gene Type |
miRNA |
| Full Name |
microRNA 448 |
Entrez |
554212
|
| Ensembl ID |
ENSG00000199001 |
HGNC |
26069
|
| Aliases |
MIRN448, hsa-mir-448, miRNA448
|
Chromosome Location |
Chromosome X, NC_000023.11 (114823454..114823564)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR448 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 26852749 |
Xuesong Wu |
2016 |
miR-448 |
These results demonstrated that miR-448 might play as a tumor suppressor miRNA partly through targeting ADAM10 expression |
Experiment for MIR448 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
40 |
40 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
Downregulated in the GC cell and tissue |
26852749 |
| cell line |
- |
- |
Cell proliferation assay; Colony formation; Invasion assay |
- |
No Reports |
- |
- |
Ectopic expression of miR-448 suppressed GC cell proliferation, colony formation, and invasion |
miR-448 suppressed the GC cell proliferation, colony formation, and invasion |
26852749 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
ADAM10 was a direct target gene of miR-448 in GC cell |
26852749 |
Function for MIR448 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for MIR448 Gene
| Interaction Gene |
Method |
PMID |
|
ADAM10 |
Luciferase reporter assay |
26852749
|
|
