Search Result
Gene Summary for MIR454 Gene
| Official Symbol |
MIR454 |
Gene Type |
miRNA |
| Full Name |
microRNA 454 |
Entrez |
768216
|
| Ensembl ID |
ENSG00000211514 |
HGNC |
33137
|
| Aliases |
MIRN454, hsa-mir-454, mir-454
|
Chromosome Location |
Chromosome 17, NC_000017.11 (59137758..59137872, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR454 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30810117 |
Datong Jiang |
2019 |
miR-454-3p |
lncRNA HOTAIR knockdown stimulates miR-454-3p expression to inhibit gastric cancer growth by depressing STAT3/Cyclin D1 activity. |
Experiment for MIR454 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
30 |
30 |
ISH |
China |
No Reports |
Down |
- |
- |
miR-454-3p expression of cancer tissues was significantly decreased compared with that of non-tumor tissues. lncRNA HOTAIR was negatively correlated with miR-454-3p expression in gastric cancer tissues. |
30810117 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
STAT3 is the target gene of miR-454-3p. |
30810117 |
Function for MIR454 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
Interaction for MIR454 Gene
| Interaction Gene |
Method |
PMID |
|
STAT3 |
Luciferase reporter assay |
30810117
|
|
