Search Result
Gene Summary for MIR490 Gene
| Official Symbol |
MIR490 |
Gene Type |
miRNA |
| Full Name |
microRNA 490 |
Entrez |
574443
|
| Ensembl ID |
ENSG00000207597 |
HGNC |
32075
|
| Aliases |
MIRN490, hsa-mir-490, miR-490
|
Chromosome Location |
Chromosome 7, NC_000007.14 (136903167..136903294)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR490 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 32293550 |
Min Luo |
2020 |
miR-490 |
Knockdown of LINC00483 inhibited gastric cancer development in vitro and in vivo by increasing miR-490-3p and decreasing MAPK1, elucidating a novel mechanism for understanding the development of gastric cancer. |
Experiment for MIR490 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
30 |
30 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
The level of miR-490-3p were decreased in gastric cancer tissues and negative correlated with the level of LINC00483 and MAPK1. Knockdown of LINC00483 or MAPK1 inhibited cells viability, migration and invasion but promoted apoptosis in gastric cancer cells. Moreover, MAPK1 overexpression attenuated the effect of LINC00483 knockdown on gastric cancer development. LINC00483 could increase MAPK1 expression by competitively sponging miR-490-3p. miR-490-3p overexpression suppressed gastric cancer development, which was abated by introduction of LINC00483. Besides, inhibition of LINC00483 decreased xenograft tumor growth by regulating miR-490-3p/MAPK1 axis. |
32293550 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
LINC00483 could increase MAPK1 expression by competitively sponging miR-490-3p. miR-490-3p overexpression suppressed gastric cancer development, which was abated by introduction of LINC00483 |
32293550 |
| cell line |
- |
- |
Cell viability assay; Invasion and migration assay; Flow cytometry |
- |
No Reports |
- |
- |
Over expression of miR-490-3p resulted in obvious reduction in viability, migration and invasion as well as increase in apoptosis of GC cells. |
Over expression of miR-490-3p resulted in obvious reduction in viability, migration and invasion as well as increase in apoptosis of GC cells. |
32293550 |
Function for MIR490 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for MIR490 Gene
| Interaction Gene |
Method |
PMID |
|
LINC00483; MAPK1 |
Luciferase reporter assay |
32293550
|
|
