Search Result
Gene Summary for MIR494 Gene
| Official Symbol |
MIR494 |
Gene Type |
miRNA |
| Full Name |
microRNA 494 |
Entrez |
574452
|
| Ensembl ID |
ENSG00000194717 |
HGNC |
32084
|
| Aliases |
MIRN494, hsa-mir-494, mir-494
|
Chromosome Location |
Chromosome 14, NC_000014.9 (101029634..101029714)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR494 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29568970 |
Zhili Shen |
2018 |
miR-494 |
Cinobufacini suppresses GC cells proliferation and promotes apoptosis partially through the regulation of miR-494-BAG-1 axis, which may provide a novel insight into the functional mechanism of cinobufacini. |
Experiment for MIR494 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| blood |
50 |
50 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
The expression level of miR-494 was lower in patients with GC than in healthy control subjects. The expression of miR-494 and BAG-1 exhibited opposing trends of in cinobufacini-treated cells, with miR-494 was upregulated and BAG-1 downregulated by cinobufacini. The miR-494 inhibitor partially reversed the cinobufacini-induced decreased expression of BAG-1. |
29568970 |
| cell line |
- |
- |
Cell proliferation assay; Flow cytometry |
- |
No Reports |
- |
- |
- |
Treatment with cinobufacini suppressed proliferation and promoted apoptosis of gastric cancer cells.knockdown of miR-494 in cinobufacini-treated cells promoted cell proliferation and inhibited cell apoptosis. Inhibition of BAG-1 in cinobufacini-treated cells partially abrogated the effects of miR-494 inhibitor on cell proliferation and apoptosis. |
29568970 |
Function for MIR494 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for MIR494 Gene
| Interaction Gene |
Method |
PMID |
|
