MKGC: a curated molecular knowledgebase for gastric cancer


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Gene Summary for MIR519D Gene

Official Symbol MIR519D Gene Type miRNA
Full Name microRNA 519d Entrez 574480
Ensembl ID ENSG00000207981 HGNC 32112
Aliases MIRN519D, mir-519d Chromosome Location Chromosome 19, NC_000019.10 (53713347..53713434)
Expression -
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Paper for MIR519D Gene

PMID Author Year ID in Paper
 Conclusion
29510377 Yong-Yuan Li 2018 miR-519d miR-519d-3p functions as a tumor suppressor by targeting and downregulating the expression of BCL6 in GC cells.

Experiment for MIR519D Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 20 20 qRT-PCR China No Reports Down - miR-519d-3p was downregulated in GC tumor tissues,associated with the clinical stage and lymph node metastasis of GC tissues. Decreased miR-519d-3p expression was associated with advanced stage and lymph node metastasis of GC compared with controls. 29510377
cell line - - Cell proliferation assay; Invasion and migration assays; Cell colony formation assay; Flow cytometry - No Reports - - miR-519d-3p inhibited MGC803 cell proliferation and invasion and delayed G1/S phase transition. miR-519d-3p inhibited MGC803 cell proliferation and invasion and delayed G1/S phase transition.miR-519d-3p/BCL6 axis inhibits cell proliferation, invasion, and cell cycle by regulating cyclin B1, E-cadherin, and MMP2 levels in GC cells. 29510377
cell line - - Luciferase reporter assay - No Reports - - - BCL6 Is the Target of miR-519d-3p 29510377
tissue 20 20 qRT-PCR China No Reports Down - miR-519d-3p was downregulated in GC tumor tissues,associated with the clinical stage and lymph node metastasis of GC tissues. Decreased miR-519d-3p expression was associated with advanced stage and lymph node metastasis of GC compared with controls. 29510377

Function for MIR519D Gene

Functional Type AUC Overall Survival Disease-free Survival
target - - -

Interaction for MIR519D Gene

Interaction Gene Method PMID
BCL6 Luciferase reporter assay 29510377
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