MKGC: a curated molecular knowledgebase for gastric cancer


Search Result

 

Gene Summary for MIR5590 Gene

Official Symbol MIR5590 Gene Type miRNA
Full Name microRNA 5590 Entrez 100847069
Ensembl ID ENSG00000263783 HGNC 43541
Aliases Chromosome Location Chromosome 2, NC_000002.12 (134857820..134857873)
Expression -
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Paper for MIR5590 Gene

PMID Author Year ID in Paper
 Conclusion
30029874 Nan Wu 2018 miR-5590-3p miR-5590-3p directly targeting DDX5 on the development of gastric cancer through salvage experiments in vivo and in vitro.

Experiment for MIR5590 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 42 42 qRT-PCR China No Reports Down - - In addition, Ago2-based RIP and dual-luciferase reporter were conducted to study the Next, were used to determine the role of miR-5590-3p in GC tumorigenicity in vivo. whereas . 30029874
cell line - - Cell proliferation assay; Cell colony formation assay; - No Reports - - miR-5590-3p regulates GC cell proliferation and colony formation by G1/S transition miR-5590-3p regulates GC cell proliferation and colony formation by G1/S transition 30029874
mice - - Xenograft mouse models - No Reports - - downregulation of miR-5590-3p promoted GC proliferation in vitro Downregulation of miR-5590-3p promoted GC proliferation in vitro 30029874
cell line - - RIP and Luciferase reporter assay - No Reports - - - miR-5590-3p as a direct target of DDX5. 30029874

Function for MIR5590 Gene

Functional Type AUC Overall Survival Disease-free Survival
target - - -

Interaction for MIR5590 Gene

Interaction Gene Method PMID
About Us      Admin
备案/许可证编号：苏ICP备2021043822号