Search Result
Gene Summary for MIR582 Gene
| Official Symbol |
MIR582 |
Gene Type |
miRNA |
| Full Name |
microRNA 582 |
Entrez |
693167
|
| Ensembl ID |
ENSG00000202601 |
HGNC |
32838
|
| Aliases |
MIRN582, hsa-mir-582
|
Chromosome Location |
Chromosome 5, NC_000005.10 (59703606..59703703, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR582 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29228422 |
Y Jin |
2017 |
MicroRNA-582 |
MiR-582-5p exerted tumor-suppressive effects on gastric cancer growth via targeting AKT3 in vitro, which provided an innovative and candidate target for diagnosis and treatment of gastric cancer |
Experiment for MIR582 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
42 |
42 |
qRT-PCR |
China |
No Reports |
|
|
- |
MiR-582-5p was downregulated in gastric cancer tissues when compared with para-carcinoma tissues. |
29228422 |
| cell line |
- |
- |
Cell proliferation assay; Cell colony formation assay; Flow cytometry |
- |
No Reports |
- |
- |
Overexpressed miR-582-5p could attenuate cell proliferation and viability capacities, as well as promoted cell apoptosis and cell cycle arrest at G0/G1 phase. |
Overexpressed miR-582-5p could attenuate cell proliferation and viability capacities, as well as promoted cell apoptosis and cell cycle arrest at G0/G1 phase. |
29228422 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
AKT3 was chosen as the target gene of miR-582-5p. Moreover, restoration of AKT3 could impair tumor suppression role of miR-582-5p on gastric cancer growth. |
29228422 |
Function for MIR582 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR582 Gene
| Interaction Gene |
Method |
PMID |
|
AKT3 |
Luciferase reporter assay |
29228422
|
|
