Search Result
Gene Summary for MIR589 Gene
| Official Symbol |
MIR589 |
Gene Type |
miRNA |
| Full Name |
microRNA 589 |
Entrez |
693174
|
| Ensembl ID |
ENSG00000207973 |
HGNC |
32845
|
| Aliases |
MIRN589, hsa-mir-589, mir-589
|
Chromosome Location |
Chromosome 7, NC_000007.14 (5495819..5495917, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR589 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30012200 |
Feifei Zhang |
2018 |
miR-589 |
miR-589, as an oncogene, markedly induced cell metastasis and invasion via an atypical miR-589-LIFR-PI3K/AKT-c-Jun feedback loop, which suggested miR-589 as a potential biomarker and/or therapeutic target for the gastric cancer management. |
Experiment for MIR589 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
34 |
34 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
MiR-589 expression was significantly higher in tumor tissues and gastric cancer cells than those in matched normal tissues and gastric epithelial cells, respectively. Overexpression of miR-589 is associated with tumor metastasis, invasion and poor prognosis of GC patients. |
30012200 |
| cell line |
- |
- |
Cell invasion and migration assays |
- |
No Reports |
- |
- |
Gain- and loss-of function experiments showed that miR-589 promoted cell migration, metastasis and invasion in vitro and lung metastasis in vivo. |
Gain- and loss-of function experiments showed that miR-589 promoted cell migration, metastasis and invasion in vitro and lung metastasis in vivo. |
30012200 |
| mice |
- |
- |
nude mouse xenograft model |
- |
No Reports |
- |
- |
Endogenous overexpression of miR-589 promotes metastasis of GC cell in vivo |
Endogenous overexpression of miR-589 promotes metastasis of GC cell in vivo |
30012200 |
| cell line |
- |
- |
Luciferase reporter assay; ChIP assay |
- |
No Reports |
- |
- |
- |
miR-589 directly targeted LIFR to activate PI3K/AKT/c-Jun signaling. c-Jun bound to the promoter region of miR-589 and activated its transcription. |
30012200 |
Function for MIR589 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR589 Gene
| Interaction Gene |
Method |
PMID |
|
