MKGC: a curated molecular knowledgebase for gastric cancer


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Gene Summary for MIR613 Gene

Official Symbol MIR613 Gene Type miRNA
Full Name microRNA 613 Entrez 693198
Ensembl ID ENSG00000207983 HGNC 32869
Aliases MIRN613, hsa-mir-613 Chromosome Location Chromosome 12, NC_000012.12 (12764649..12764743)
Expression -
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Paper for MIR613 Gene

PMID Author Year ID in Paper
Conclusion
28701053 Yebin Lu 2018 MicroRNA-613 the results revealed that miR-613, as a tumour suppressor, involves in gastric cancer progression and metastasis by targeting CDK9, implying a novel potential therapeutic target for the treatment of gastric cancer.

Experiment for MIR613 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 52 52 qRT-PCR China No Reports Down - - miR-613 was evidently downregulated in gastric cancer tissue and cell. 28701053
cell line - - Luciferase reporter assay - No Reports - - - CDK9 is a direct target of miR-613 in gastric cancer 28701053
cell line - - Cell proliferation assay; Invasion and migration assays; - No Reports - - miR-613 suppressed cell proliferation and migration in gastric cancer miR-613 suppressed cell proliferation and migration in gastric cancer 28701053

Function for MIR613 Gene

Functional Type AUC Overall Survival Disease-free Survival
target - - -

Interaction for MIR613 Gene

Interaction Gene Method PMID
CDK9 Luciferase reporter assay 28701053
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