Search Result
Gene Summary for MIR613 Gene
Official Symbol |
MIR613 |
Gene Type |
miRNA |
Full Name |
microRNA 613 |
Entrez |
693198
|
Ensembl ID |
ENSG00000207983 |
HGNC |
32869
|
Aliases |
MIRN613, hsa-mir-613
|
Chromosome Location |
Chromosome 12, NC_000012.12 (12764649..12764743)
|
Expression |
-
|
Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR613 Gene
PMID |
Author |
Year |
ID in Paper
|
Conclusion |
28701053 |
Yebin Lu |
2018 |
MicroRNA-613 |
the results revealed that miR-613, as a tumour suppressor, involves in gastric cancer progression and metastasis by targeting CDK9, implying a novel potential therapeutic target for the treatment of gastric cancer. |
Experiment for MIR613 Gene
Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
tissue |
52 |
52 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
miR-613 was evidently downregulated in gastric cancer tissue and cell. |
28701053 |
cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
CDK9 is a direct target of miR-613 in gastric cancer |
28701053 |
cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays; |
- |
No Reports |
- |
- |
miR-613 suppressed cell proliferation and migration in gastric cancer |
miR-613 suppressed cell proliferation and migration in gastric cancer |
28701053 |
Function for MIR613 Gene
Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
target |
- |
- |
- |
Interaction for MIR613 Gene
Interaction Gene |
Method |
PMID |
CDK9 |
Luciferase reporter assay |
28701053
|
|