Search Result
Gene Summary for MIR615 Gene
| Official Symbol |
MIR615 |
Gene Type |
miRNA |
| Full Name |
microRNA 615 |
Entrez |
693200
|
| Ensembl ID |
ENSG00000207571 |
HGNC |
32871
|
| Aliases |
MIRN615, hsa-mir-615, mir-615
|
Chromosome Location |
Chromosome 12, NC_000012.12 (54033950..54034045)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR615 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29501762 |
Jizhao Wang |
2018 |
miR-615-3p |
miR-615-3p promotes gastric cancer proliferation and migration by suppressing CELF2 expression for the first time, providing clues for future clinical practices |
Experiment for MIR615 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
104 |
104 |
qRT-PCR |
China |
No Reports |
Up |
Up |
- |
Aberrant high expression of miR-615-3p and low expression of CELF2 in gastric cancer both in vivo and in vitro. Moreover, miR-615-3p expression correlated to T and M stage. Higher expression of miR-615-3p correlated to shorter period of survival months. |
29501762 |
| cell line |
- |
- |
Cell proliferation assay; Flow cytometry; Cell migration assay |
- |
No Reports |
- |
- |
miR-615-3p inhibits apoptosis and promotes proliferation and migration ability in SGC7901 cell line. Overexpression of CELF2 could reverse miR-615-3p's oncogenic functions stated before. |
miR-615-3p inhibits apoptosis and promotes proliferation and migration ability in SGC7901 cell line. Overexpression of CELF2 could reverse miR-615-3p's oncogenic functions stated before. |
29501762 |
Function for MIR615 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
< 0.05 |
- |
Interaction for MIR615 Gene
| Interaction Gene |
Method |
PMID |
|
