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Gene Summary for MIR644A Gene

Official Symbol MIR644A Gene Type miRNA
Full Name microRNA 644a Entrez 693229
Ensembl ID ENSG00000207997 HGNC 32900
Aliases MIR644; MIRN644; hsa-mir-644; hsa-mir-644a Chromosome Location Chromosome 20, NC_000020.11 (34466325..34466418)
Expression -
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Paper for MIR644A Gene

PMID Author Year ID in Paper
 Conclusion
27983935 Yingchao Li 2018 miR-644a through targeting CtBP1-mediated suppression of the EMT process, miR-644a might suppress the tumor metastasis of GC cells.

Experiment for MIR644A Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 107 107 qRT-PCR China No Reports Down Down - The expression of miR-644a was suppressed in GC tissues and was associated with a later clinical stage and tumor metastasis. 27983935
cell line - - Cell proliferation assay; Cell invasion and migration assays - No Reports - - Restoring the expression of miR-644a could significantly suppress the migration and invasion of HGC-27 and SGC-7901 cells, which might be correlated to its suppressive effect on the EMT process. We also found that carboxyl-terminal-binding protein 1 (CtBP1) was a putative target gene of miR-644a in GC and might be involved in the suppressive effect Restoring the expression of miR-644a could significantly suppress the migration and invasion of HGC-27 and SGC-7901 cells, which might be correlated to its suppressive effect on the EMT process. 27983935
cell line - - Luciferase reporter assay - No Reports - - - CtBP1 is a putative target gene of miR-644a in GC cells 27983935

Function for MIR644A Gene

Functional Type AUC Overall Survival Disease-free Survival
target - - -

Interaction for MIR644A Gene

Interaction Gene Method PMID
CTBP1 Luciferase reporter assay 27983935
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