MKGC: a curated molecular knowledgebase for gastric cancer


Search Result

 

Gene Summary for MIR675 Gene

Official Symbol MIR675 Gene Type miRNA
Full Name microRNA 675 Entrez 100033819
Ensembl ID ENSG00000284010 HGNC 33351
Aliases MIRN675, hsa-mir-675 Chromosome Location Chromosome 11, NC_000011.10 (1996759..1996831, complement)
Expression -
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Paper for MIR675 Gene

PMID Author Year ID in Paper
 Conclusion
28848149 Jin Yan 2017 miR-675 A novel regulatory pathway H19/miR-675/ FADD/caspase 8/caspase 3 in gastric cancer which may be potential target for cancer therapy.

Experiment for MIR675 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 34 34 qRT-PCR;Western blot China No Reports Up - - miR-675 were increased in gastric cancer cell lines and tissues. H19 and miR-675 expression was positively correlated in gastric cancer tissues. 28848149
cell line - - Luciferase reporter assay - No Reports - - - FADD is a potential target of miR-675; H19/miR-675 axis inhibited expression of FADD. FADD downregulation subsequently inhibited the caspase cleavage cascades including caspase 8 and caspase 3. 28848149
cell line - - Cell proliferation assay; Colony formation assay; Flow cytometry - No Reports - - Overexpression of H19 and miR-675 promoted cell proliferation and inhibited cell apoptosis, whereas knockdown of H19 and miR-675 inhibited these effects. Overexpression of H19 and miR-675 promoted cell proliferation and inhibited cell apoptosis, whereas knockdown of H19 and miR-675 inhibited these effects. 28848149
mice - - Xenograft mice models - No Reports - - - There was a dramatic decrease in in tumor volume and weight in nude mice in which LV- shH19 infected SGC-7901 cell. co-infection with LV-miR675 partially reversed this tendency. 28848149

Function for MIR675 Gene

Functional Type AUC Overall Survival Disease-free Survival
target - - -

Interaction for MIR675 Gene

Interaction Gene Method PMID
H19 Luciferase reporter assay 28848149
About Us      Admin
备案/许可证编号：苏ICP备2021043822号