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Gene Summary for MIR711 Gene
| Official Symbol |
MIR711 |
Gene Type |
miRNA |
| Full Name |
microRNA 711 |
Entrez |
100313843
|
| Ensembl ID |
ENSG00000284251 |
HGNC |
37316
|
| Aliases |
hsa-mir-711
|
Chromosome Location |
Chromosome 3, NC_000003.12 (48578902..48578977, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR711 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 26735582 |
Aijun Liao |
2016 |
miR-711 |
RASSF1A inhibits the proliferation of gastric cancer cells by upregulating the expression of miR-711, which arrested gastric cancer cells in the G1 phase by downregulating expression of CDK4. This finding might provide us with a novel therapeutic target for gastric cancer by increasing RASSF1A expression via miR-711 regulation. |
Experiment for MIR711 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
28 |
28 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
The expression of miR-711 was lower in the cancer tissues than in the normal tissues. |
26735582 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays; Flow cytometry |
- |
No Reports |
- |
- |
- |
miR-711 could suppress SGC-7901 cell growth in a time-dependent manner. |
26735582 |
| cell line |
- |
- |
Flow cytometry; Western blot |
- |
No Reports |
- |
- |
- |
miR-711 was found to downregulate CDK4 expression |
26735582 |
Function for MIR711 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR711 Gene
| Interaction Gene |
Method |
PMID |
|
