Gastric Cancer Database

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MIR9-1
MIR9-1

Gene Summary for MIR9-1 Gene

Official Symbol	MIR9-1	Gene Type	miRNA
Full Name	microRNA 9-1	Entrez	407046
Ensembl ID	ENSG00000207933	HGNC	31641
Aliases	MIRN9-1; mir-9-1; miRNA9-1; hsa-mir-9-1	Chromosome Location	Chromosome 1, NC_000001.11 (156420341..156420429, complement)
Expression	-
Summary	microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Paper for MIR9-1 Gene

PMID	Author	Year	ID in Paper	Conclusion
23383271	Liduan Zheng	2013	microRNA-9	anti-miR-9 inhibitor promoted the proliferation, migration and invasion of gastric cancer cells, while knocking down of cyclin D1 or Ets1 partially phenocopied the effects of miR-9 overexpression.
21225631	Pichayanoot Rotkrua	2011	CDX2	miR-9 might repress CDX2 expression via the binding site in the 30-UTR, resulting in the promotion of cell proliferation in GCs.

Experiment for MIR9-1 Gene

Sample Type	Sample Number GC	Sample Number nonGC	Method	Region	Hpylori	Normal vs. GC	Early-stage vs. Advanced stage	Biological Functions in GC Cells	Result	PMID
tissue	86	86	qRT-PCR	China	No Reports	Down	-	-	miR-9 was found to be down-regulated and inversely correlated with the expression of cyclin D1 and v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets1) in gastric cancer tissues and cell lines. The miR-9 expression was significantly lower in gastric cancer cases with deeper gastric wall invasion, lymph node metastasis, distant metastasis, and advanced TNM stage.	23383271
cell line	-	-	Cell proliferation assay; Invasion and migration assays; Flow Cytometry; Cell colony formation assay	-	No Reports	-	-	miR-9 suppressed the in vitro proliferation of gastric cancer cells through targeting cyclin D1; miR-9 attenuated the in vitro migration and invasion of gastric cancer cells through targeting Ets1	miR-9 suppressed the in vitro proliferation of gastric cancer cells through targeting cyclin D1; miR-9 attenuated the in vitro migration and invasion of gastric cancer cells through targeting Ets1	23383271
cell line	-	-	Luciferase reporter assay	-	No Reports	-	-	-	miR-9 directly targeted cyclin D1 and Ets1 in gastric cancer cells	23383271
mice	-	-	Xenograft mice models	-	No Reports	-	-	-	miR-9 attenuated the growth and metastasis of gastric cancer cells in vivo	23383271
tissue	27	-	qRT-PCR	Japan	No Reports	-	-	-	Amounts of miR-9 in the CDX2-negative group were significantly higher than those in the CDX2-positive group.	21225631
cell line	-	-	Luciferase reporter assay	-	No Reports	-	-	-	MiR-9 interacts with a putative binding site in the CDX2 3'-UTR	21225631
cell line	-	-	Cell proliferation assay; Flow cytometry	-	No Reports	-	-	Suppression of miR-9 and overexpression of CDX2 elicit the same phenomenon of cell cycle arrest	Suppression of miR-9 and overexpression of CDX2 elicit the same phenomenon of cell cycle arrest	21225631

Function for MIR9-1 Gene

Functional Type	AUC	Overall Survival	Disease-free Survival
mechanism	-	-	-

Interaction for MIR9-1 Gene

Interaction Gene	Method	PMID
CCND1;ETS1	Luciferase reporter assay	23383271
CDX3	Luciferase reporter assay	21225631

Gene Summary for MIR9-1 Gene

Official Symbol	MIR9-1	Gene Type	miRNA
Full Name	microRNA 9-1	Entrez	407046
Ensembl ID	ENSG00000207933	HGNC	31641
Aliases	MIRN9-1, hsa-mir-9-1, miRNA9-1, mir-9-1	Chromosome Location	Chromosome 1, NC_000001.11 (156420341..156420429, complement)
Expression	-
Summary	microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Paper for MIR9-1 Gene

PMID	Author	Year	ID in Paper	Conclusion
23383271	Liduan Zheng	2013	microRNA-9	anti-miR-9 inhibitor promoted the proliferation, migration and invasion of gastric cancer cells, while knocking down of cyclin D1 or Ets1 partially phenocopied the effects of miR-9 overexpression.
21225631	Pichayanoot Rotkrua	2011	CDX2	miR-9 might repress CDX2 expression via the binding site in the 30-UTR, resulting in the promotion of cell proliferation in GCs.

Experiment for MIR9-1 Gene

Sample Type	Sample Number GC	Sample Number nonGC	Method	Region	Hpylori	Normal vs. GC	Early-stage vs. Advanced stage	Biological Functions in GC Cells	Result	PMID
tissue	86	86	qRT-PCR	China	No Reports	Down	-	-	miR-9 was found to be down-regulated and inversely correlated with the expression of cyclin D1 and v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets1) in gastric cancer tissues and cell lines. The miR-9 expression was significantly lower in gastric cancer cases with deeper gastric wall invasion, lymph node metastasis, distant metastasis, and advanced TNM stage.	23383271
cell line	-	-	Cell proliferation assay; Invasion and migration assays; Flow Cytometry; Cell colony formation assay	-	No Reports	-	-	miR-9 suppressed the in vitro proliferation of gastric cancer cells through targeting cyclin D1; miR-9 attenuated the in vitro migration and invasion of gastric cancer cells through targeting Ets1	miR-9 suppressed the in vitro proliferation of gastric cancer cells through targeting cyclin D1; miR-9 attenuated the in vitro migration and invasion of gastric cancer cells through targeting Ets1	23383271
cell line	-	-	Luciferase reporter assay	-	No Reports	-	-	-	miR-9 directly targeted cyclin D1 and Ets1 in gastric cancer cells	23383271
mice	-	-	Xenograft mice models	-	No Reports	-	-	-	miR-9 attenuated the growth and metastasis of gastric cancer cells in vivo	23383271
tissue	27	-	qRT-PCR	Japan	No Reports	-	-	-	Amounts of miR-9 in the CDX2-negative group were significantly higher than those in the CDX2-positive group.	21225631
cell line	-	-	Luciferase reporter assay	-	No Reports	-	-	-	MiR-9 interacts with a putative binding site in the CDX2 3'-UTR	21225631
cell line	-	-	Cell proliferation assay; Flow cytometry	-	No Reports	-	-	Suppression of miR-9 and overexpression of CDX2 elicit the same phenomenon of cell cycle arrest	Suppression of miR-9 and overexpression of CDX2 elicit the same phenomenon of cell cycle arrest	21225631

Function for MIR9-1 Gene

Functional Type	AUC	Overall Survival	Disease-free Survival
mechanism	-	-	-

Interaction for MIR9-1 Gene

Interaction Gene	Method	PMID
CCND1;ETS1	Luciferase reporter assay	23383271
CDX3	Luciferase reporter assay	21225631

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