Search Result
Gene Summary for MIR99A Gene
| Official Symbol |
MIR99A |
Gene Type |
miRNA |
| Full Name |
microRNA 99a |
Entrez |
407055
|
| Ensembl ID |
ENSG00000207638 |
HGNC |
31650
|
| Aliases |
MIRN99A, mir-99a
|
Chromosome Location |
Chromosome 21, NC_000021.9 (16539089..16539169)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR99A Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30156609 |
Pei Liu |
2018 |
microRNA-99a |
It provided a novel regulatory mechanism for ANRIL in gastric cancer, in which ANRIL silence down-regulated BMI1 via miR-99a, along with activation of the apoptotic pathway and inhibition of the Notch and mTOR pathways |
Experiment for MIR99A Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
20 |
20 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
The miR-99a expression in gastric tumor tissues was significantly lower than that in non-tumorous tissues. |
30156609 |
Function for MIR99A Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for MIR99A Gene
| Interaction Gene |
Method |
PMID |
|
