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Gene Summary for MIRLET7A1 Gene
| Official Symbol |
MIRLET7A1 |
Gene Type |
miRNA |
| Full Name |
microRNA let-7a-1 |
Entrez |
406881
|
| Ensembl ID |
ENSG00000199165 |
HGNC |
31476
|
| Aliases |
LET7A1, MIRNLET7A1, let-7a-1
|
Chromosome Location |
Chromosome 9, NC_000009.12 (94175957..94176036)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIRLET7A1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 23519840 |
Wei-ning Wang |
2013 |
let-7a |
CCR7 protein plays a key role in the metastasis and progression of gastric cancer. The elevated CCR7 protein expression may be caused by the deficiency of let-7a miRNA expression due to the downregulation of DICER1gene expression. The mechanism for the silencing of DICER1 gene expression requires further studies. |
Experiment for MIRLET7A1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| serum |
80 |
45 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
Let-7a miRNA expression was significantly lower in the serum of cancer patients than in the serum of healthy individuals. The serum let-7a level significantly correlated with its level in tumor tissues. |
23519840 |
| tissue |
80 |
40 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
Let-7a miRNA expression was significantly lower in gastric adenocarcinoma tissues than in peritumoral tissues |
23519840 |
| cell line |
- |
- |
Cell invasion and migration assays |
- |
No Reports |
- |
- |
Let-7a miRNA transfection significantly inhibited the migration and invasion in MNK-45 cells |
Let-7a miRNA transfection significantly inhibited the migration and invasion in MNK-45 cells |
23519840 |
Function for MIRLET7A1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for MIRLET7A1 Gene
| Interaction Gene |
Method |
PMID |
|
