MKGC: a curated molecular knowledgebase for gastric cancer


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Gene Summary for MIRLET7G Gene

Official Symbol MIRLET7G Gene Type miRNA
Full Name microRNA let-7g Entrez 406890
Ensembl ID ENSG00000199150 HGNC 31485
Aliases LET7G, MIRNLET7G, hsa-let-7g, let-7g Chromosome Location Chromosome 3, NC_000003.12 (52268278..52268361, complement)
Expression -
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Paper for MIRLET7G Gene

PMID Author Year ID in Paper
 Conclusion
25288334 Wei Kang 2014 let-7g Decreased let-7b/g contributes to aberrant AKT activation in gastric tumorigenesis and provide a potential therapeutic strategy for gastric cancer.

Experiment for MIRLET7G Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 76 76 qRT-PCR China No Reports Down - - let-7g was found down-regulated in gastric cancer and correlated with N-stage and lymph node metastasis. AKT2 mRNA expression showed negative correlation with the expression of let-7g in primary tumors. 25288334
cell line - - Cell proliferation assay; Invasion assay; Cell colony fomation assay - No Reports - - suppressed the growth and invasive capacityof GC cells suppressed the growth and invasive capacityof GC cells 25288334
mice - - Xenograft mouse models - No Reports - - let-7b/g transfectants formed smaller xenografts than those scramble transfectants let-7b/g transfectants formed smaller xenografts than those scramble transfectants 25288334
cell line - - Luciferase reporter assay - No Reports - - - let-7b/g inhibited AKT2 expression by directly binding to its 3'UTR, reduced p-AKT (S473) activation and suppressed expression of the downstream effector pS6. 25288334

Function for MIRLET7G Gene

Functional Type AUC Overall Survival Disease-free Survival
target - - 0.051

Interaction for MIRLET7G Gene

Interaction Gene Method PMID
AKT2 Luciferase reporter assay 25288334
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