Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
tissue |
10 |
10 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
NMRAL2P was downregulated in tumor tissues and GC cell lines. |
32469171 |
cell line |
- |
- |
Cell proliferation assay; Flow cytometry; Transwell assay |
- |
No Reports |
- |
- |
Overexpression of NMRAL2P inhibits cell proliferation, cell cycle progression, cell migration, and invasion and promotes cell apoptosis in GC cells |
NMRAL2P overexpression induced a more malignant phenotype and significantly inhibited the expression of ACOT7. |
32469171 |
cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
NMRAL2P indirectly methylated ACOT7 by binding to DNMT3b, thereby suppressing ACOT7 expression. |
32469171 |