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Gene Summary for NOTCH4 Gene
| Official Symbol |
NOTCH4 |
Gene Type |
protein-coding |
| Full Name |
notch receptor 4 |
Entrez |
4855
|
| Ensembl ID |
ENSG00000204301 |
HGNC |
7884
|
| Aliases |
INT3
|
Chromosome Location |
Chromosome 6, NC_000006.12 (32194843..32224067, complement)
|
| Expression |
Broad expression in fat (RPKM 20.5), lung (RPKM 16.6) and 21 other tissues
|
| Summary |
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
|
Paper for NOTCH4 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 25511451 |
Cuijuan Qian |
2015 |
Notch4 |
Notch4 activates Wnt1/β-catenin signaling to regulate GC growth. |
Experiment for NOTCH4 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
75 |
75 |
IHC |
China |
No Reports |
Up |
- |
- |
Notch4 was activated by overexpressing exogenous intracellular domain of Notch4 (ICN4). Activated Notch4 expression levels were up-regulated in GC tissues |
25511451 |
| cell line |
- |
- |
Cell proliferation assay |
- |
No Reports |
- |
- |
- |
Notch4 activation promoted GC growth in vitro, while Notch4 inhibition using ICN4 siRNA had opposite effects. |
25511451 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
Notch4 activation promotes tumor growth in vivo, while Notch4 inhibition inhibits tumor growth in vivo |
25511451 |
Function for NOTCH4 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for NOTCH4 Gene
| Interaction Gene |
Method |
PMID |
|
