MKGC: a curated molecular knowledgebase for gastric cancer


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Gene Summary for PDCD4 Gene

Official Symbol PDCD4 Gene Type protein-coding
Full Name programmed cell death 4 Entrez 27250
Ensembl ID ENSG00000150593 HGNC 8763
Aliases H731 Chromosome Location Chromosome 10, NC_000010.11 (110871928..110900006)
Expression Ubiquitous expression in colon (RPKM 80.4), thyroid (RPKM 70.8) and 25 other tissues
Summary This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Paper for PDCD4 Gene

PMID Author Year ID in Paper
 Conclusion
27634902 Kai Yin 2016 PDCD4 This study revealed a critical role for miR-208a-3p as an oncogenic miRNA in gastric carcinogenesis and it may provide a potential novel target for gastric cancer diagnosis and therapy

Experiment for PDCD4 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 16 16 IHC China No Reports Down - - PDCD4 protein expression is down-regulated in GC tissues. 27634902
cell line - - Flow cytometry - No Reports - - MKN45 cells transfected with the PDCD4 siRNA showed suppression of cell apoptosis, whereas overexpression of PDCD4 significantly promoted cell apoptosis MKN45 cells transfected with the PDCD4 siRNA showed suppression of cell apoptosis, whereas overexpression of PDCD4 significantly promoted cell apoptosis 27634902
cell line - - Luciferase reporter assay - No Reports - - - PDCD4 is a direct target of miR-208a-3p 27634902
mice - - Xenograft mice models - No Reports - - - PDCD4 inhabit the development of tumor growth 27634902

Function for PDCD4 Gene

Functional Type AUC Overall Survival Disease-free Survival
target - - -

Interaction for PDCD4 Gene

Interaction Gene Method PMID
miR-208a-3p Luciferase reporter assay 27634902
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