Search Result
Gene Summary for PIK3R1 Gene
| Official Symbol |
PIK3R1 |
Gene Type |
protein-coding |
| Full Name |
phosphoinositide-3-kinase regulatory subunit 1 |
Entrez |
5295
|
| Ensembl ID |
ENSG00000145675 |
HGNC |
8979
|
| Aliases |
AGM7, GRB1, IMD36, p85, p85-ALPHA
|
Chromosome Location |
Chromosome 5, NC_000005.10 (68215737..68301821)
|
| Expression |
Ubiquitous expression in fat (RPKM 16.6), brain (RPKM 16.6) and 24 other tissues
|
| Summary |
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
|
Paper for PIK3R1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30927924 |
Xiaoxu Huang |
2019 |
PIK3R1 |
circAKT3 plays an important role in the resistance of GC to CDDP. Thus, our results highlight the potential of circAKT3 as a therapeutic target for GC patients receiving CDDP therapy. |
Experiment for PIK3R1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
44 |
- |
qRT-PCR |
China |
No Reports |
- |
- |
- |
PIK3R1 was upregulated in DDP-resistant GC tissues samples when compared with CDDP-senestive groups. |
30927924 |
| cell line |
- |
- |
Western blot |
- |
No Reports |
- |
- |
- |
CDDP-resistant GC cells showed obvious increases in the expression of PIK3R1 mRNA and protein levels. |
30927924 |
| cell line |
- |
- |
Luciferase reporter assay; Western blot; qRT-PCR |
- |
No Reports |
- |
- |
miR-198 |
PIK3R1 is a direct target of miR-198; miR-198 mimics significantly inhibited PIK3R1 mRNA and protein levels and that ectopic PIK3R1 expression abolished the influence caused by miR-198 overexpression. |
30927924 |
Function for PIK3R1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for PIK3R1 Gene
| Interaction Gene |
Method |
PMID |
|
