Search Result
Gene Summary for PKM Gene
| Official Symbol |
PKM |
Gene Type |
protein-coding |
| Full Name |
pyruvate kinase M1/2 |
Entrez |
5315
|
| Ensembl ID |
ENSG00000067225 |
HGNC |
9021
|
| Aliases |
CTHBP, HEL-S-30, OIP3, PK32, TCB, THBP1, p58, PKM
|
Chromosome Location |
Chromosome 15, NC_000015.10 (72199029..72231389, complement)
|
| Expression |
Ubiquitous expression in brain (RPKM 155.4), esophagus (RPKM 151.3) and 24 other tissues
|
| Summary |
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]
|
Paper for PKM Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 28588255 |
Chao Wang |
2017 |
PKM2 |
Our results obtained from in vitro cell biological behavior, in vivo tumorigenicity studies, and primary GC samples revealed an oncogenic role for PKM2 in GC. Furthermore, for those GC patients who received radical resection, PKM2 might serve as a novel prognostic biomarker and target which would allow for a brand new treatment strategy for GC in the clinical settings. |
Experiment for PKM Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
88 |
88 |
IHC |
China |
No Reports |
Up |
- |
- |
PKM2 protein was predominantly located in the nucleus and cytoplasma, and was observed to have higher IHC scores in gastric cancer samples than in peritumor tissues; PKM2 expression was positively correlated with lymph node metastasis, tumor invasion and TNM staging. |
28588255 |
| cell line |
- |
- |
Cell proliferation assay; Cell colony formation assay; Invasion and migration assays; Flow cytometry |
- |
No Reports |
- |
- |
- |
knockdown of PKM2 can inhibit GC cell proliferation, G1-S phase transition,especially, attenuate GC cell migration |
28588255 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
PKM2 knockdown inhibits the tumor progression of GC in vivo. |
28588255 |
| cell line |
- |
- |
Western blot; cell transduction |
- |
No Reports |
- |
- |
- |
PKM2 mediates cell migration and autophagy via the PI3K/Akt signaling pathway. |
28588255 |
Function for PKM Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target/prognosis |
- |
0.006 |
- |
Interaction for PKM Gene
| Interaction Gene |
Method |
PMID |
|
