Search Result
Gene Summary for POU2F1 Gene
| Official Symbol |
POU2F1 |
Gene Type |
protein-coding |
| Full Name |
POU class 2 homeobox 1 |
Entrez |
5451
|
| Ensembl ID |
ENSG00000143190 |
HGNC |
9212
|
| Aliases |
OCT1, OTF1, oct-1B
|
Chromosome Location |
Chromosome 1, NC_000001.11 (167220878..167427345)
|
| Expression |
Ubiquitous expression in testis (RPKM 2.5), brain (RPKM 2.3) and 25 other tissues
|
| Summary |
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]
|
Paper for POU2F1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 25678401 |
Song-Hui Xu |
2015 |
POU2F1 |
ACK1 promotes EMT, migration, and invasion by activating AKT-POU2F1-ECD signalling in GC cells. ACK1 may be employed as a new prognostic factor and therapeutic target for GC. |
Experiment for POU2F1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
77 |
77 |
IHC |
China |
No Reports |
Up |
- |
- |
POU2F1 was overexpressed in GC tissues than in normal tissues, and its protein levels had a positive correlation with ACK1protein level. |
25678401 |
| cell line |
- |
- |
Luciferase reporter assay;ChIP assay |
- |
No Reports |
- |
- |
- |
POU2F1 directly binds to the ECD gene promoter and induces ECD expression. |
25678401 |
| cell line |
- |
- |
Cell invasion and migration assays |
- |
No Reports |
- |
- |
POU2F1 silencing blocked the migration, invasion, and EMT processes induced by ACK1 overexpression in gC cells |
POU2F1 silencing blocked the migration, invasion, and EMT processes induced by ACK1 overexpression in gC cells |
25678401 |
Function for POU2F1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
Interaction for POU2F1 Gene
| Interaction Gene |
Method |
PMID |
|
