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Gene Summary for RASSF1 Gene
| Official Symbol |
RASSF1 |
Gene Type |
protein-coding |
| Full Name |
Ras association domain family member 1 |
Entrez |
11186
|
| Ensembl ID |
ENSG00000068028 |
HGNC |
9882
|
| Aliases |
123F2, NORE2AA, RDA32, REH3P21, RASSF1
|
Chromosome Location |
Chromosome 3, NC_000003.12 (50329786..50340836, complement)
|
| Expression |
Ubiquitous expression in bone marrow (RPKM 19.8), spleen (RPKM 15.6) and 25 other tissues
|
| Summary |
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]
|
Paper for RASSF1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 26735582 |
Aijun Liao |
2016 |
RASSF1A |
RASSF1A inhibits the proliferation of gastric cancer cells by upregulating the expression of miR-711, which arrested gastric cancer cells in the G1 phase by downregulating expression of CDK4. This finding might provide us with a novel therapeutic target for gastric cancer by increasing RASSF1A expression via miR-711 regulation. |
Experiment for RASSF1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
28 |
28 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
The expression of RASSF1A was lower in the cancer tissues than in the normal tissues. |
26735582 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays; Flow cytometry |
- |
No Reports |
- |
- |
- |
The expression of RASSF1A could suppress the viability, migration and invasion capacity of SGC-7901 cell in vitro. |
26735582 |
| cell line |
- |
- |
miRNA microarray; qRT-PCR |
- |
No Reports |
- |
- |
- |
The expression of miR-711 was higher in the pcDNA3.1-RASSF1A-transfected SGC-7901 cells than in the pcDNA3.1-vector-transfected SGC-7901 cells. |
26735582 |
Function for RASSF1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for RASSF1 Gene
| Interaction Gene |
Method |
PMID |
|
