Search Result
Gene Summary for RB1 Gene
| Official Symbol |
RB1 |
Gene Type |
protein-coding |
| Full Name |
RB transcriptional corepressor 1 |
Entrez |
5925
|
| Ensembl ID |
ENSG00000139687 |
HGNC |
9884
|
| Aliases |
OSRC, PPP1R130, RB, p105-Rb, p110-RB1, pRb, pp110
|
Chromosome Location |
Chromosome 13, NC_000013.11 (48303751..48481890)
|
| Expression |
Ubiquitous expression in lymph node (RPKM 18.0), thyroid (RPKM 16.4) and 25 other tissues
|
| Summary |
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
|
Paper for RB1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 15818729 |
Xiu-Sheng He |
2005 |
Rb |
The loss protein expression of p16 and Rb genes is related to GC. The loss expression of P16 protein is related to the histopathologic subtypes and lymph node metastasis of GC. Expression of P16 and Rb proteins in GC is reversely correlated. The deletion but not mutation in exon 2 of p16 gene may be involved in GC. |
| 14691913 |
Roger M Feakins |
2003 |
pRb |
Rb pathway disturbances play an important role in gastric carcinogenesis. The poor prognosis of cancers with low pRb expression and the reduced pRb expression in lymph node metastases raise the possibility that Rb and related genes also influence progression. |
Experiment for RB1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
122 |
80 |
S-P |
China |
No Reports |
Down |
- |
- |
The positive rates of Rb protein expression respectively were 99% (79/80) in normal gastric mucosa, 80% (40/50) in dysplastic gastric mucosa, 60% (73/122) in GC. The positive rates of Rb protein expression in GC were significantly lower than that in normal gastric mucosa and dysplastic gastric mucosa (P<0.05). The positive rate of both P16 and Rb proteins was 16% (14/90), and the negative rate of both P16 and Rb proteins was 8% (7/90) in 90 GCs. The rate of positive P16 protein with negative Rb protein was 33% (30/90). The rate of negative P16 protein with positive Rb protein was 43% (39/90). There was reverse correlation between P16 and Rb expression in 90 GCs. |
15818729 |
| tissue |
67 |
67 |
IHC |
U.K. |
No Reports |
- |
- |
- |
pRb expression was lower in lymph node metastases than in the corresponding primary tumors; low pRb expression may be a powerful independent negative prognostic factor. |
14691913 |
Function for RB1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
0.0027 |
- |
Interaction for RB1 Gene
| Interaction Gene |
Method |
PMID |
|
