Search Result
Gene Summary for RUNX3 Gene
| Official Symbol |
RUNX3 |
Gene Type |
protein-coding |
| Full Name |
RUNX family transcription factor 3 |
Entrez |
864
|
| Ensembl ID |
ENSG00000020633 |
HGNC |
10473
|
| Aliases |
AML2, CBFA3, PEBP2aC
|
Chromosome Location |
Chromosome 1, NC_000001.11 (24899511..24965158, complement)
|
| Expression |
Biased expression in bone marrow (RPKM 19.5), spleen (RPKM 16.7) and 12 other tissues
|
| Summary |
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
|
Paper for RUNX3 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 20300977 |
Shi-Lian Hu |
2011 |
Runx3 |
Aberrant promoter methylation of Runx3 and CHFR genes may be involved in the carcinogenesis and development of GC and may provide useful clues for the prediction of the malignant behaviors of GC. |
Experiment for RUNX3 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
123 |
123 |
MS-PCR; BGS |
China |
No Reports |
Up(Methylation) |
- |
- |
The methylation frequencies of Runx3 in cancer tissues were significantly higher than those in corresponding normal gastric mucosae. The methylation status of Runx3 was inversely related to the tumor size. |
20300977 |
| tissue |
123 |
- |
RT-PCR; IHC |
China |
No Reports |
- |
- |
- |
The expression of the protein and mRNA decreased remarkably in the patients with aberrant promoter methylation of Runx3 genes. |
20300977 |
| tissue |
123 |
- |
IHC |
China |
No Reports |
- |
- |
- |
The protein expression of Runx3 were significantly correlated with tumor invasion depth. |
20300977 |
Function for RUNX3 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
Interaction for RUNX3 Gene
| Interaction Gene |
Method |
PMID |
|
