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Gene Summary for SFRP1 Gene
| Official Symbol |
SFRP1 |
Gene Type |
protein-coding |
| Full Name |
secreted frizzled related protein 1 |
Entrez |
6422
|
| Ensembl ID |
ENSG00000104332 |
HGNC |
10776
|
| Aliases |
FRP, FRP-1, FRP1, FrzA, SARP2
|
Chromosome Location |
Chromosome 8, NC_000008.11 (41261962..41309473, complement)
|
| Expression |
Broad expression in endometrium (RPKM 97.0), fat (RPKM 58.4) and 17 other tissues
|
| Summary |
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
|
Paper for SFRP1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29886152 |
Hai-Bin Cui |
2018 |
SFRP1 |
miR-208a promoted GC progression by targeting SFRP1 and negatively regulating MEG3, which may be a potential therapeutic target of GC. |
Experiment for SFRP1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Cell proliferation assay; Cell invasion assay; |
- |
No Reports |
- |
- |
SFRP1 partially reverses the effects of miR-208a on proliferation and invasion in GC |
SFRP1 partially reverses the effects of miR-208a on proliferation and invasion in GC |
29886152 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
SFRP1 is a direct target of MiR-208a in GC cells |
29886152 |
Function for SFRP1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for SFRP1 Gene
| Interaction Gene |
Method |
PMID |
|
miR-208a |
Luciferase reporter assay |
29886152
|
|
