Search Result
Gene Summary for SIRT1 Gene
| Official Symbol |
SIRT1 |
Gene Type |
protein-coding |
| Full Name |
sirtuin 1 |
Entrez |
23411
|
| Ensembl ID |
ENSG00000096717 |
HGNC |
14929
|
| Aliases |
SIR2, SIR2L1, SIR2alpha
|
Chromosome Location |
Chromosome 10, NC_000010.11 (67884656..67918390)
|
| Expression |
Ubiquitous expression in adrenal (RPKM 17.4), testis (RPKM 16.6) and 25 other tissues
|
| Summary |
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
|
Paper for SIRT1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30250020 |
Guoying Dong |
2018 |
SIRT1 |
SIRT1 suppresses migration and invasion of GC by downregulating ARHGAP5 through an interaction with c-JUN, and these phenomena represent a novel mechanism of the antitumor action of SIRT1. |
Experiment for SIRT1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Cell invasion and migration assays |
- |
No Reports |
- |
- |
knockdown of SIRT1 promoted GC cell migration and invasion in vitro and metastasis in vivo. |
knockdown of SIRT1 promoted GC cell migration and invasion in vitro and metastasis in vivo. Forced expression of SIRT1 in GC cells had the opposite effects. SIRT1 inhibited the expression of ARHGAP5 by physically associating with transcription factor c-JUN and deacetylating and inhibiting the transcriptional activity of c-JUN. |
30250020 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
SIRT1 inhibits metastasis of GC in vivo |
30250020 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
SIRT1 inhibits expression of ARHGAP5 by physically interacting with and deacetylating c-JUN |
30250020 |
Function for SIRT1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for SIRT1 Gene
| Interaction Gene |
Method |
PMID |
|
JUN |
Luciferase reporter assay |
30250020
|
|
