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Gene Summary for SKP2 Gene
| Official Symbol |
SKP2 |
Gene Type |
protein-coding |
| Full Name |
S-phase kinase associated protein 2 |
Entrez |
6502
|
| Ensembl ID |
ENSG00000145604 |
HGNC |
10901
|
| Aliases |
FBL1, FBXL1, FLB1, p45
|
Chromosome Location |
Chromosome 5, NC_000005.10 (36152067..36184319)
|
| Expression |
Broad expression in placenta (RPKM 19.8), lymph node (RPKM 3.9) and 22 other tissues
|
| Summary |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]
|
Paper for SKP2 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 27572672 |
Yanguang Wen |
2016 |
Skp2 |
Abrogating the effects of Skp2 may effectively inhibit the growth of gastric cancer cells, which may be useful as a novel target in the clinical treatment of gastric cancer. |
Experiment for SKP2 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
47 |
19 |
Western blot |
China |
No Reports |
Up |
- |
- |
The expression levels of Skp2 in the gastric cancer tissues were significantly increased, compared with those in the normal gastric tissues |
27572672 |
| cell line |
- |
- |
Cell proliferation assay |
- |
No Reports |
- |
- |
Defective regulation of Skp2 or the presence of Skp2 inhibitor contribute to decreased proliferation in human gastric cancer cell lines.Skp2 inhibitor inhibits the proliferation of gastric cancer cells in a dose‑dependent manner |
Defective regulation of Skp2 or the presence of Skp2 inhibitor contribute to decreased proliferation in human gastric cancer cell lines.Skp2 inhibitor inhibits the proliferation of gastric cancer cells in a dose‑dependent manner |
27572672 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
Interference with the endogenous expression of Skp2 inhibits tumor cell growth in nude mice. |
27572672 |
Function for SKP2 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for SKP2 Gene
| Interaction Gene |
Method |
PMID |
|
