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Gene Summary for SOX9 Gene
| Official Symbol |
SOX9 |
Gene Type |
protein-coding |
| Full Name |
SRY-box transcription factor 9 |
Entrez |
6662
|
| Ensembl ID |
ENSG00000125398 |
HGNC |
11204
|
| Aliases |
CMD1, CMPD1, SRA1, SRXX2, SRXY10
|
Chromosome Location |
Chromosome 17, NC_000017.11 (72121020..72126416)
|
| Expression |
Broad expression in testis (RPKM 26.5), brain (RPKM 25.2) and 17 other tissues
|
| Summary |
The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008]
|
Paper for SOX9 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30154451 |
Tingting Li |
2018 |
SOX9 |
These findings indicated that COL10A1 might play a crucial role in GC progression and serve as a potential biomarker and therapeutic target in GC patients. |
Experiment for SOX9 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
30 |
30 |
qRT-PCR; Western blot |
China |
No Reports |
Up |
- |
- |
SOX9 was up-regulated in GC. We observed a positive correlation between the expression patterns of SOX9 and COL10A1 in GC cells and tissues. |
30154451 |
| tissue |
103 |
- |
qRT-PCR |
China |
No Reports |
- |
- |
- |
The mRNA expression level of SOX9 was significantly associated with tumor size, lymphatic emboli, lymph node metastasis, serosal invasion, AJCC stage, and recur_x005frence risk. |
30154451 |
| tissue |
99 |
99 |
IHC |
China |
No Reports |
Up |
- |
- |
The protein expression level of SOX9 was significantly upregulated in GC tissues and showed high concordance. The protein expression levels of COL10A1 and SOX9 were significantly correlated with tumor size, tumor differentiation, lymph node metastasis, and serosal invasion. The protein expression level of COL10A1 was associated with AJCC stage. COL10A1 was associated with a poor prognosis in GC patients. |
30154451 |
| cell line |
- |
- |
Luciferase reporter assay; ChIP assay |
- |
No Reports |
- |
- |
- |
SOX9 directly binds to the COL10A1 promoter and activates its transcription. |
30154451 |
Function for SOX9 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
0 |
- |
Interaction for SOX9 Gene
| Interaction Gene |
Method |
PMID |
|
