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Gene Summary for STAT3 Gene
| Official Symbol |
STAT3 |
Gene Type |
protein-coding |
| Full Name |
signal transducer and activator of transcription 3 |
Entrez |
6774
|
| Ensembl ID |
ENSG00000168610 |
HGNC |
11364
|
| Aliases |
ADMIO, ADMIO1, APRF, HIES
|
Chromosome Location |
Chromosome 17, NC_000017.11 (42313324..42388502, complement)
|
| Expression |
Ubiquitous expression in gall bladder (RPKM 47.5), lung (RPKM 47.3) and 25 other tissues
|
| Summary |
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020]
|
Paper for STAT3 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30810117 |
Datong Jiang |
2019 |
STAT3 |
lncRNA HOTAIR knockdown stimulates miR-454-3p expression to inhibit gastric cancer growth by depressing STAT3/Cyclin D1 activity. |
Experiment for STAT3 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
30 |
30 |
IHC |
China |
No Reports |
Up |
- |
- |
STAT3 protein expressions were significantly upregulated in cancer tissues.lncRNA HOTAIR was positively correlated with STAT3 and Cyclin D1 protein expressions in gastric cancer tissues. |
30810117 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
STAT3 is the target gene of miR-454-3p. |
30810117 |
Function for STAT3 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for STAT3 Gene
| Interaction Gene |
Method |
PMID |
|
miR-454-3p |
Luciferase reporter assay |
30810117
|
|
