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Gene Summary for SUFU Gene
| Official Symbol |
SUFU |
Gene Type |
protein-coding |
| Full Name |
SUFU negative regulator of hedgehog signaling |
Entrez |
51684
|
| Ensembl ID |
ENSG00000107882 |
HGNC |
16466
|
| Aliases |
JBTS32, PRO1280H, SUFUXL, SUFU
|
Chromosome Location |
Chromosome 10, NC_000010.11 (102502801..102633535)
|
| Expression |
Ubiquitous expression in skin (RPKM 4.8), ovary (RPKM 4.2) and 25 other tissues
|
| Summary |
The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
|
Paper for SUFU Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 27810403 |
Yin Peng |
2017 |
SUFU |
miRNA-194 is oncogenic and promotes GC cell proliferation and migration by activating Wnt signaling, at least in part, via suppression of SUFU. |
Experiment for SUFU Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
SUFU is the functional target of miRNA-194 |
27810403 |
| tissue |
75 |
75 |
IHC |
China |
No Reports |
Down |
- |
- |
SUFU was significantly down expressed in GCs compared to NSs. The expression level of SUFU was negatively associated with tumor stage. |
27810403 |
| tissue |
20 |
20 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
SUFU mRNA was significantly down expressed in GCs; a negative relationship between miRNA-194 and SUFU expression levels |
27810403 |
Function for SUFU Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for SUFU Gene
| Interaction Gene |
Method |
PMID |
|
miRNA-194 |
Luciferase reporter assay |
27810403
|
|
