Search Result
Gene Summary for TET2 Gene
| Official Symbol |
TET2 |
Gene Type |
protein-coding |
| Full Name |
tet methylcytosine dioxygenase 2 |
Entrez |
54790
|
| Ensembl ID |
ENSG00000168769 |
HGNC |
25941
|
| Aliases |
MDS; IMD75; KIAA1546
|
Chromosome Location |
Chromosome 4, NC_000004.12 (105145875..105279803)
|
| Expression |
Ubiquitous expression in bone marrow (RPKM 5.5), appendix (RPKM 4.6) and 25 other tissues
|
| Summary |
The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
|
Paper for TET2 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 31242038 |
Wei Deng |
2019 |
TET2 |
Patients with higher TET2 expression survived better, while with higher ANRIL survived worse. Furthermore, expressions of TET2 and ANRIL were negatively correlated in the patient samples |
Experiment for TET2 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
192 |
- |
qRT-PCR |
China |
No Reports |
- |
- |
- |
Patients with high TET2 expression had significantly longer survival time. |
31242038 |
| cell line |
- |
- |
Apoptosis assay; Migration assay |
- |
No Reports |
- |
- |
TET2 decreased gastric cancer cell survival |
TET2 decreased gastric cancer cell survival and suppressed metastasis |
31242038 |
| mice |
- |
- |
Xenograft mouse model |
- |
No Reports |
- |
- |
TET2 suppresses tumor growth in vivo |
TET2 suppresses tumor growth in vivo |
31242038 |
Function for TET2 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
< 0.01 |
- |
Interaction for TET2 Gene
| Interaction Gene |
Method |
PMID |
|
