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Gene Summary for TGFBR1 Gene
| Official Symbol |
TGFBR1 |
Gene Type |
protein-coding |
| Full Name |
transforming growth factor beta receptor 1 |
Entrez |
7046
|
| Ensembl ID |
ENSG00000106799 |
HGNC |
11772
|
| Aliases |
AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TBR-i, TBRI, TGFR-1, tbetaR-I
|
Chromosome Location |
Chromosome 9, NC_000009.12 (99104038..99154192)
|
| Expression |
Ubiquitous expression in placenta (RPKM 13.6), gall bladder (RPKM 8.0) and 24 other tissues
|
| Summary |
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
|
Paper for TGFBR1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 31182928 |
Luo Zhang |
2019 |
TGFBR1 |
The circCACTIN/miR-331-3p/TGFBR1 axis affected the proliferation, migration, invasion and EMT of GC through the mechanism of competing endogenous RNAs (ceRNA). Furthermore, our results identified circCACTIN as a novel oncogenic circRNA in GC. |
Experiment for TGFBR1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
30 |
30 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
TGFBR1 was significantly overexpressed in GC tissues.TGFBR1 expression was positively related to circCACTIN in si-circCACTIN group BGC-823 cells and LV-circCACTIN group MGC-803 cells. |
31182928 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays |
- |
No Reports |
- |
- |
- |
TGFBR1 played a vital role in GC cells proliferation, invasion, migration, and EMT, which was positively regulated by circCACTIN. |
31182928 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
Binding interaction exists between miR-331-3p and TGFBR1. |
31182928 |
Function for TGFBR1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for TGFBR1 Gene
| Interaction Gene |
Method |
PMID |
|
miR-331-3p |
Luciferase reporter assay |
31182928
|
|
