MKGC: a curated molecular knowledgebase for gastric cancer


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Gene Summary for TMEM41A Gene

Official Symbol TMEM41A Gene Type protein-coding
Full Name transmembrane protein 41A Entrez 90407
Ensembl ID ENSG00000163900 HGNC 30544
Aliases 2900010K02Rik Chromosome Location Chromosome 3, NC_000003.12 (185482671..185499057, complement)
Expression Ubiquitous expression in small intestine (RPKM 11.1), duodenum (RPKM 11.1) and 25 other tissues
Summary -

Paper for TMEM41A Gene

PMID Author Year ID in Paper
 Conclusion
30015937 Bin Lin 2018 TMEM41A TMEM41A may be considered as a novel therapeutic target for the treatment of GC-associated metastasis.

Experiment for TMEM41A Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 147 147 qRT-PCR China No Reports Up Up - TMEM41A was highly expressed in GC tissues, its expression of TMEM41A was observed to be correlated with lymph node metastasis, distant metastasis and advanced tumor, node and metastasis stages.Patients with GC and high expression levels of TMEM41A exhibited a poorer disease‑free survival following radical tumor resection. 30015937
cell line - - Cell proliferation assay; Invasion and migration assays; Cell immunofluorescence for cytoskeleton stain and autophagy - No Reports - - Knockdown of TMEM41A in vitro decreased the GC cell migration ability by regulating epithelial-to-mesenchymal transition and cell autophagy, via the upregulation of E-cadherin and downregulating N-cadherin expression in GC cells. Knockdown of TMEM41A in vitro decreased the GC cell migration ability by regulating epithelial-to-mesenchymal transition and cell autophagy, via the upregulation of E-cadherin and downregulating N-cadherin expression in GC cells. 30015937
mice - - Xenograft mice models - No Reports - - - Knockdown of TMEM41A was also observed to affect tumor metastasis in nude mice. 30015937

Function for TMEM41A Gene

Functional Type AUC Overall Survival Disease-free Survival
target - - -

Interaction for TMEM41A Gene

Interaction Gene Method PMID
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