Search Result
Gene Summary for TNK2 Gene
| Official Symbol |
TNK2 |
Gene Type |
protein-coding |
| Full Name |
tyrosine kinase non receptor 2 |
Entrez |
10188
|
| Ensembl ID |
ENSG00000061938 |
HGNC |
19297
|
| Aliases |
ACK, ACK-1, ACK1, p21cdc42Hs
|
Chromosome Location |
Chromosome 3, NC_000003.12 (195863364..195908551, complement)
|
| Expression |
Ubiquitous expression in brain (RPKM 21.9), bone marrow (RPKM 14.7) and 24 other tissues
|
| Summary |
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
|
Paper for TNK2 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 25678401 |
Song-Hui Xu |
2015 |
ACK1 |
ACK1 promotes EMT, migration, and invasion by activating AKT-POU2F1-ECD signalling in GC cells. ACK1 may be employed as a new prognostic factor and therapeutic target for GC. |
Experiment for TNK2 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
6 |
6 |
Western blot |
China |
No Reports |
Up |
- |
- |
ACK1 protein level and ACK1 phosphorylation at Tyr 284 were frequently elevated in GC tissues. |
25678401 |
| tissue |
77 |
77 |
IHC |
China |
No Reports |
Up |
- |
- |
ACK1 overexpression in GC correlates with poor prognosis; positively associated with lymph node metastasis and a more advanced clinical stage in GC |
25678401 |
| cell line |
- |
- |
Cell invasion and migration assays |
- |
No Reports |
- |
- |
ACK1 induces EMT, invasion, and metastasis |
ACK1 induces EMT, invasion, and metastasis |
25678401 |
| cell line |
- |
- |
Western blot; Luciferase reporter assay; IHC |
- |
No Reports |
- |
- |
- |
ACK1 up-regulates ECD expression by increasing the level of POU2F1. |
25678401 |
Function for TNK2 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target/prognosis |
- |
< 0.001 |
- |
Interaction for TNK2 Gene
| Interaction Gene |
Method |
PMID |
|
