Search Result
Gene Summary for UCA1 Gene
| Official Symbol |
UCA1 |
Gene Type |
lncRNA |
| Full Name |
urothelial cancer associated 1 |
Entrez |
652995
|
| Ensembl ID |
ENSG00000214049 |
HGNC |
37126
|
| Aliases |
CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36
|
Chromosome Location |
Chromosome 19, NC_000019.10 (15828947..15836321)
|
| Expression |
Biased expression in gall bladder (RPKM 19.1), endometrium (RPKM 12.1) and 5 other tissues
|
| Summary |
This gene produces a long non-coding RNA that was found to be upregulated in bladder cancer and plays a regulatory role in cell proliferation. This transcript regulates several genes, including CREB (cAMP responsive element binding protein). Expression of this transcript is regulated by CCAAT/enhancer-binding protein-alpha. [provided by RefSeq, Dec 2017]
|
Paper for UCA1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 28569779 |
Zhen-Qiang Wang |
2017 |
UCA1 |
UCA1 as a critical regulator involved in GC proliferation and cell cycle progression by promoting cyclin D1 expression, which indicates that it may be clinically a potential therapeutic target in GC. |
Experiment for UCA1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
39 |
39 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
UCA1 expressed highly in GC tissues and GC cells, overexpression of UCA1 indicated higher tumor stage and lymph node metastasis in GC patients. |
28569779 |
Function for UCA1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for UCA1 Gene
| Interaction Gene |
Method |
PMID |
|
