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Gene Summary for VEGFC Gene
| Official Symbol |
VEGFC |
Gene Type |
protein-coding |
| Full Name |
vascular endothelial growth factor C |
Entrez |
7424
|
| Ensembl ID |
ENSG00000150630 |
HGNC |
12682
|
| Aliases |
VRP; Flt4-L; LMPH1D; LMPHM4
|
Chromosome Location |
Chromosome 4, NC_000004.12 (176683538..176792922, complement)
|
| Expression |
Broad expression in thyroid (RPKM 17.4), placenta (RPKM 7.1) and 21 other tissues
|
| Summary |
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]
|
Paper for VEGFC Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 24337012 |
Junyan Zhang |
2014 |
survivin |
VEGF-C |
Experiment for VEGFC Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
195 |
- |
IHC; TMA |
China |
No Reports |
- |
- |
- |
The expression levels of VEGF-C was significantly higher in patients with lymph node metastasis than in those without metastasis. Patients with high expression levels of VEGF-C showed significantly less favorable survival rates compared with patients with low expression levels of it. |
24337012 |
Function for VEGFC Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
0.039 |
- |
Interaction for VEGFC Gene
| Interaction Gene |
Method |
PMID |
|
