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Gene Summary for XRCC5 Gene
| Official Symbol |
XRCC5 |
Gene Type |
protein-coding |
| Full Name |
X-ray repair cross complementing 5 |
Entrez |
7520
|
| Ensembl ID |
ENSG00000079246 |
HGNC |
12833
|
| Aliases |
KARP-1, KARP1, KU80, KUB2, Ku86, NFIV
|
Chromosome Location |
Chromosome 2, NC_000002.12 (216109348..216206293)
|
| Expression |
Ubiquitous expression in thyroid (RPKM 87.8), lymph node (RPKM 70.4) and 25 other tissues
|
| Summary |
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
|
Paper for XRCC5 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30217218 |
Zhuoyu Gu |
2018 |
XRCC5 |
Our findings indicate that overexpression of CLC-3 is regulated by XRCC5 and is a poor prognostic biomarker for gastric cancer. Double targeting CLC-3 and XRCC5 may provide the promising therapeutic potential for GC treatment. |
Experiment for XRCC5 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
90 |
90 |
IHC |
China |
No Reports |
Up |
- |
- |
XRCC5 was localized to the nucleus, and its expression was higher in GC tissues than that in normal tissues. The expression of CLC-3 and XRCC5 was positively correlated. High expression of XRCC5 predicted a poor prognosis for GC patients. |
30217218 |
| cell line |
- |
- |
Cell proliferation assay; Cell invasion and migration assays; |
- |
No Reports |
- |
- |
knockdown of XRCC5 attenuated the cell clonogenicity, proliferation,invasion and migration. |
knockdown of XRCC5 attenuated the cell clonogenicity, proliferation,invasion and migration. |
30217218 |
| cell line |
- |
- |
Luciferase reporter assay;ChIP assay |
- |
No Reports |
- |
- |
- |
XRCC5 was identified as a CLC-3 promoter-binding protein, and both CLC-3 and XRCC5 were prognostic factors of overall survival in GC patients. |
30217218 |
Function for XRCC5 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
< 0.01 |
- |
Interaction for XRCC5 Gene
| Interaction Gene |
Method |
PMID |
|
