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Gene Summary for YBX1 Gene
| Official Symbol |
YBX1 |
Gene Type |
protein-coding |
| Full Name |
Y-box binding protein 1 |
Entrez |
4904
|
| Ensembl ID |
ENSG00000065978 |
HGNC |
8014
|
| Aliases |
BP-8, CBF-A, CSDA2, CSDB, DBPB, EFI-A, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1
|
Chromosome Location |
Chromosome 1, NC_000001.11 (42682418..42703805)
|
| Expression |
Ubiquitous expression in testis (RPKM 220.6), fat (RPKM 121.2) and 25 other tissues
|
| Summary |
This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015]
|
Paper for YBX1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 25959498 |
Yongchao Liu |
2015 |
YBX1 |
These results delineate a novel mechanism of lncRNA GAS5 in suppressing stomach carcinogenesis, and the lncRNA GAS5/YBX1/p21 pathway we discovered may provide useful targets for developing lncRNA-based therapies for stomach cancer. |
Experiment for YBX1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
RNA pull-down assay |
- |
No Reports |
- |
- |
- |
lncRNA GAS5 interacts with the transcriptional activator YBX1. |
25959498 |
| cell line |
- |
- |
Flow cytometry |
- |
No Reports |
- |
- |
YBX1 depletion reduces G1 phase arrest by decreasing p21 expression. |
YBX1 depletion reduces G1 phase arrest by decreasing p21 expression. |
25959498 |
Function for YBX1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for YBX1 Gene
| Interaction Gene |
Method |
PMID |
|
