MKGC: a curated molecular knowledgebase for gastric cancer


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Gene Summary for ZNF143 Gene

Official Symbol ZNF143 Gene Type protein-coding
Full Name zinc finger protein 143 Entrez 7702
Ensembl ID ENSG00000166478 HGNC 12928
Aliases SBF, STAF, pHZ-1 Chromosome Location Chromosome 11, NC_000011.10 (9460982..9528524)
Expression Ubiquitous expression in testis (RPKM 5.8), lymph node (RPKM 4.3) and 25 other tissues
Summary -

Paper for ZNF143 Gene

PMID Author Year ID in Paper
 Conclusion
27449034 Song Wei 2016 ZNF143 ZNF143 expressed strongly in GC and enhanced migration of GC cells in vitro and in vivo. It is conceivable that ZNF143 could be a therapeutic genetic target for GC treatment.

Experiment for ZNF143 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 53 53 qRT-PCR China No Reports Up - ZNF143 level is upregulated in gastric cancer and highly correlated with the presence of lymph node metastasis. 27449034
tissue 12 12 IHC China No Reports Up - - Protein level of ZNF143 is higher in GC tssues and staining in the nucleus of GC cells 27449034
cell line - - Cell invasion and migration assays - No Reports - - ZNF143 knockdown inhibits the migration and invasion of gastric cancer cells, and overexpression contributes to the migration and invasion of GC cells. ZNF143 knockdown inhibits the migration and invasion of gastric cancer cells, and overexpression contributes to the migration and invasion of GC cells. 27449034
mice - - Xenograft mice models - No Reports - - - ZNF143 knockdown suppresses metastases of GC cells in vivo 27449034
cell line - - Western blot; cell transfection - No Reports - - - Overexpression of ZNF143 re- duced the expression of epithelial cell marker (E-cadherin) and induced the expression mesenchymal cell marker (N-cadherin, Vimentin), related transcription factors (snail, slug), and upregulated the expression of phosphorylation AKT. 27449034

Function for ZNF143 Gene

Functional Type AUC Overall Survival Disease-free Survival
target - - -

Interaction for ZNF143 Gene

Interaction Gene Method PMID
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